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Moreover, pretreatment with Wuzhi tablet suppressed the p53/p21 signalling pathway, which induces cell proliferation proteins that enhance proliferation of hepatocytes

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The UK regulator recommends that in adults weighing less than 50 kg, ‘clinical judgement’ should be employed when prescribing oral paracetamol as these patients may be at increased ‘risk of hepatotoxicity’ but does not specify a dose reduction