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3.2 Related signaling pathways 3.2.1 NF-κB/MAPK NF-κB is a critical transcription factor involved in many biological processes and its overactivation may disrupt the intestinal barrier via various mechanisms and thus affect the development of IBD, including UC (Zhang et al., 2017)

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1113 Made in China Manufactured for: Dynarex Corporation Orangeburg, NY 10962 www.dynarex.com Revised: 11/2019 PRINCIPAL DISPLAY PANEL: B-12 Compliance Injection Kit NDC 49836-527-01 RX-Only B-12 Compliance Injection Kit Kit Contains: 1 Cyanocobalamin Injection, USP 1,000 mcg/mL (1 mL) 1 Sterile Isopropyl Alcohol 70% Prep Pad 1 Pair Nitrile Powder Free sterile Gloves (Size 7.5) 1 Sterile Towel Drape 1 Sterile Adhesive Bandage 1 Dose Needles and Syringes Not Included B-12 Compliance Injection Kit DISTRIBUTED BY: SCHMIGS HAUPPAUGE, NY 11788 NDC 49836-527-01 MANUFACTURED BY: Rx Pharma Pack HAUPPAUGE, NY 11788 Questions/Comments 1-844-632-7898 Kit Contents: Cyanocobalamin Injection, USP 1,000 mcg/mL* (Manufactured by American Regent) Each mL contains: benzyl alcohol 1.5%