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Based on these data, the FDA approved tesamorelin (marketed as EGRIFTA) for the reduction of excess abdominal fat in HIV‑associated lipodystrophy, not as a general weight‑loss drug for the wider population.​ Tesamorelin Risks and Considerations Like all hormone‑modulating therapies, tesamorelin carries potential risks, including fluid retention, joint pain, injection‑site reactions, and effects on glucose metabolism in susceptible patients

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A meta-analysis of studies using NAC to increase athletic performance found that there were more side effects (none severe) at 20g/day.[ref] High doses of NAC are used in hospitals by IV for reversing acetaminophen toxicity

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