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[Google Scholar] 4.Wolfman N.M., Hattersley G., Cox K., Celeste A.J., Nelson R., Yamaji N., Dube J.L., Di Blasio-Smith E., Nove J., Song J.J., et al

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It attributes the low oral bioavailability to limited intestinal absorption plus heavy first-pass metabolism, supported by a half-life under 7 minutes and clearance of 57.9 mL/min/kg in mouse hepatocytes