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A drug called apitegromab may help to preserve lean body mass during weight loss with tirzepatide, a GLP-1 receptor agonist, according to a phase 2 clinical trial published in Nature Medicine. The

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In a randomized, double-blind, placebo-controlled trial in 2,919 participants (≥65 years) with elevated blood concentrations of homocysteine, supplementation with vitamin B 12 (500 μg/day) and folic acid (400 μg/day) for two years did not decrease the risk of osteoporotic fracture despite reductions in homocysteine (120, 121)