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urinaria possesses anti-inflammatory properties, can prevent macrophage M2 type polarization through the NF-κB signaling pathway, promote M1 type transformation, and provide resistance against HCC

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Alterations in microbial communities and their metabolites have been linked to key pathological features of PCOS (116, 117), including insulin resistance, hyperandrogenism, and chronic low-grade inflammation, supporting the concept of a gut–metabolism–reproductive axis in which intestinal microbial ecosystems influence both metabolic and endocrine homeostasis (23, 73)