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This information is key for identifying pathway-biased agonists that avoid beta-arrestin-mediated side effects (e.g., tolerance), thereby supporting lead optimization and selection of safer, more efficacious candidates before preclinical studies

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At some point, each of us failed enough points on the sobriety tests — things like walking in a straight line while counting out our steps, balancing on one leg while holding the other leg out straight about six inches off the ground with the foot angled “as if you’re standing on a soda can,” and vision checks — that had we been driving before doing these tests, we were informed we would’ve been put in handcuffs