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Improved Sleep Quality Many clients report better sleep after beginning B12 therapy: Helps regulate circadian rhythms and sleep-wake cycles Supports production of melatonin, the sleep hormone Reduces daytime fatigue that can disrupt sleep patterns Helps balance neurotransmitters involved in sleep regulation Quality sleep further enhances energy levels, creating a positive cycle of improvement

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However, a sex-specific effect was observed, with reduced cancer incidence and mortality in men but not in women, potentially linked to lower baseline antioxidant status in men, particularly β-carotene levels (347)