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A pharmacovigilance analysis of large databases found copper deficiency reported in 100 of 2,646 (3.8%) adults on oral zinc, with an adjusted reporting odds ratio of 3.51 (95% CI 2.51-4.90) per 1 mg/kg/day of zinc, higher with chronic kidney disease, age 70 or over and female sex, a median onset of 137 days, and cytopenia in 85% to 93% of cases (pharmacovigilance study