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Disclosure of interest: none E-Posters - RISK FACTORS - PRIMARY AND SECONDAR PREVENTION 05.00 - RISK FACTORS AND PREVENTION (PRIMARY AND SECONDARY) - 05.02 - SECONDARY PREVENTION P2464 - ESOC25-245 NON-PERSISTENCE TO ORAL ANTICOAGULATION IS ASSOCIATED WITH ADVERSE CLINICAL OUTCOMES WITHIN 24 MONTHS AFTER ISCHAEMIC STROKE OR TIA IN REGISTRY PATIENTS WITH ATRIAL FIBRILLATION Manuel C

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Conservative stacking protocols start with lower tirzepatide doses (5–10mg weekly) and moderate 5-amino-1MQ doses (50mg daily) to minimize additive metabolic stress while monitoring tolerability