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High dose vitamin C is generally synergistic with glutathione (vitamin C actually recycles oxidized glutathione back to its active form), but mega doses above 2,000 mg taken at the same moment as oral glutathione can compete for absorption in the gut

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In preclinical studies, obese primates treated for eight weeks with the MC4R agonist RM-493 (Setmelanotide) lost an average of 13.5% of their body weight, with significant improvements in both insulin sensitivity and cardiovascular function