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210,211 The activation of NF-κB signaling is usually initiated by external stimuli such as cytokines or bacterial lipopolysaccharides, which bind to their corresponding receptors and trigger downstream signaling pathways

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Note, the cytoprotection concept made by Robert (prevention of stomach epithelial cell necrosis) [41,42,43,44] and Szabo (endothelium protection) [45,46,47,48,49,50] links the original protection of stomach epithelial cells to the protection of other organs (organoprotection) [42,47] (i.e., for eye pharmacotherapy, stomach epithelium behaves like eye epithelium [15]), and stomach-cytoprotective agents to agents with pleiotropic beneficial effect [42,47]