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Adding digestive enzymes like amylase,31 lipase,32 and protease can start the breakdown process before food reaches your compromised intestines, ensuring that you’re still getting most of the necessary nutrients from your diet.33 Zinc Having too little zinc can worsen your intestinal permeability.34 For more than two decades, clinical researchers have known that adding zinc to your diet can reinforce tight junctions.35 Zinc helps maintain a robust immune system, promote cell growth, build protein, and heal damaged tissue, all of which can improve the symptoms of leaky gut.34 Tryptophan Tryptophan is an essential amino acid

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However, this significance was not observed in the meta-analysis of the two randomized controlled trials (RCTs) conducted exclusively in vivo