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Common Side Effects The most frequently reported side effects are mild and typically occur during the initial adjustment period

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It's found on: Pituitary somatotrophs (direct GH release) Hypothalamic neurons in the arcuate nucleus (modulates GHRH/somatostatin neurons) Vagal afferents and brainstem nuclei (appetite/reward signaling) Other peripheral tissues This broader expression pattern means GHRPs have effects beyond just GH release: Appetite stimulation - GHSR activation in the hypothalamus and brainstem drives hunger signaling Reward pathway modulation - GHSR is expressed in dopaminergic circuits Gastric motility effects - Ghrelin/GHRPs can promote gastric emptying Practical implication: You commonly see appetite-related effects with GHRPs because ghrelin biology is built to connect "energy intake" with endocrine output