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Also, NSAIDs, while lacking addictive potential, can cause a range of complications, such as upper gastrointestinal bleeding [23,66] and renal dysfunction [67,68]

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Telomerase activation and telomere elongation: Telomeres — the repetitive DNA sequences (TTAGGG in humans) capping chromosome ends — shorten with each cell division, eventually triggering cellular senescence (permanent growth arrest) or apoptosis (programmed cell death) when they reach a critically short length