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Recently, the same group went on to identify an important A disintegrin and metalloprotease 17 (ADAM17)-regulated β 1 -AR cleavage site at Arg31-Leu32 in the N-terminus, shown to be a key contributor to H 2 O 2 -dependent β 1 -AR downregulation and decreased catecholamine responsiveness in cardiomyocytes (Zhu and Steinberg, 2021)

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