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Repeated treatment with a far-infrared sauna has been shown to significantly lower fasting blood glucose levels.[75] When insulin resistant diabetic mice were subjected to 30 minutes of heat treatment three times a week for 12 weeks, they experienced a 31 percent decrease in plasma insulin levels and a significant reduction in blood glucose levels, suggesting re-sensitisation to insulin.[76] The heat treatment specifically targeted the skeletal muscle by increasing the expression of a type of transporter known as GLUT 4, which is responsible for transporting glucose into skeletal muscle from the bloodstream.[76] Decreased glucose uptake by skeletal muscle is one of the mechanisms that leads to insulin resistance